Friday, January 24, 2014

lncRNA function

ncRNA Categories
ncRNAs:
  • housekeeping ncNRAs (e.g. ribosomal, transfer, snRNAs, snoRNAs)
  • regulatory ncRNAs (e.g. miRNAs, piRNAs, siRNAs and lncRNAs)
  • other regulatory ncRNAs (e.g. promoter-associated RNAs (PARs) and enhancer RNAs (eRNAs))

LncRNAs may have different roles:
  • gene activators (signaling),
  • repressors (decoy),
  • cis and trans gene expression regulators (guides) and
  • chromatin modificators (scaffolds) without the need to be mutually exclusive.

lncRNA types:
  • sense/antisense
  • bidirectional
  • intronic
  • intergenic

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